What is the Function of Inhibin in our Body?
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The reproductive system is regulated by different complex functions and mechanisms that involve different organs such as the brain, gonads and endocrine system. Inhibin was described as the substance produces in the gonads that negatively regulate pituitary secretion.
Its current understanding in physiology and pathology in humans suggests that inhibin may be important as a marker of Sertoli cell function in men and infertility and a prognostic indicator in women’s ovulation. The concentration of inhibin increased in patients in post-menopausal women with ovarian cancers and granulosa cell tumors.
Our Reproductive System
Inhibin is a protein hormone both produced by the female ovaries an male testes. Its function is to provide feedback messages to the anterior pituitary to block the release of follicle stimulating hormone or FSH. There are two forms of inhibin, females secrets both Inhibin A and B while males only secrete inhibin-B
Inhibin helps the suppression in releasing of follicle stimulating hormones in women by, hampering the release of mature eggs. However, if the inhibin level increases to the point of dropping the activin levels in females can lead to infertility.
As for men, it stimulates testosterone production and enhances sterility. When inhibin B is released into the bloodstream it stimulates sperm production.
The timing and amount of the released FSH by the anterior pituitary can change throughout the ovulatory cycle. It is influenced by many factors such as the sudden demise of the corpus luteum which immediately precedes menstruation. During a menstrual cycle, a large amount of estradiol, progesterone and inhibin A on FSH secretion are lost.
The sudden rise of FSH during menstruation helps stimulates the growth of antral follicles and granulosa cell proliferation. It also encourages the stimulation of androgens and testosterone to become estrogens. With this function, it increases estradiol and inhibin B concentration and feedback mechanisms come to play a consequential reduction of FSH. While the formation of corpus lutheum, increased estradiol and progesterone suppress the FSH release until the next menstruation.
FSH is a hormone that conveys many roles, it promotes granulosa cell proliferation and differentiation, antral follicle development, estrogen production, LH receptors induction, and inhibin synthesis.
Where to Find Further Research
Inhibin competes with the hormone activin and blocks its effects. It works in a feedback loop with follicle stimulating hormones and stimulates the gonads to throw more inhibin. In return, the inhibin production blocks FSH release from the pituitary gland. It is important to find a reputable research study and develop reliable results. Here at Ansh Labs, we dedicate ourselves from our beginnings, committed to identify and develop research for emerging biomarkers. Contact us for more details.